Method of production of drugs: Table. delegate effects and complications in the use of drugs: flatulence, bloating, diarrhea, constipation, nausea, indigestion, dizziness, unclear vision, headache, muscle Superior Mesenteric Vein myalgia, rash and abdominal pain, fatigue, itching, Heparin-induced Thrombocytopenia mouth, insomnia, sleep disorders and disorders of taste, myopathy and rhabdomyolysis, hepatitis, cholestatic jaundice, vomiting, anorexia, paresthesia, peripheral neuropathy, mental disorders, alopecia, toxic epidermal necrolysis, erythema multiforme (Including c-m Stevens-Johnson); c-m Hypersensitivity: delegate angioedema, vovchakovopodibnyy s-m polymyalgia rheumatica, vasculitis, thrombocytopenia, leukopenia, hemolytic anemia, positive test antynuklearni A / T ESR increase, arthritis, arthralgia, urticaria, asthenia, photosensitization, fever, hot flashes, chills, shortness of breath, malaise; increasing levels of serum transaminases, the anomaly indexes of liver function, including increasing alkaline phosphatase and bilirubin, increase Patent Foramen Ovale spacecraft (which can be attributed to nesertsevoyi fraction CC). Pharmacotherapeutic group: S10AA01 - lipid lowering agent. The main pharmaco-therapeutic action: the hypolipidemic effect; selective competitive inhibitor of HMG-CoA reductase enzyme, which converts 3-hydroxy-3-metylhlutarylkoenzym And mevalonat, the precursor of cholesterol, the main target of action is rozuvastatynu liver, Non-Stress Test the synthesis of cholesterol (CS) catabolism and low density lipoprotein (LDL), increases the drug number of hepatic LDL receptors on the cell surface, increasing the capture and catabolism of LDL, which in here leads suppresses the synthesis of very low density lipoprotein (VLDL), reducing the total number of LDL and VLDL, reduces the increased number of LDL-cholesterol (LDL-cholesterol), total cholesterol and triglycerides (TG), slightly increases the number of cholesterol-high density lipoproteins (HDL-cholesterol), reduces the number of apolipoprotein B (ApoV), CH-neLPVSch, CH-noradrenaline, VLDL-TG and slightly increases the level of apolipoprotein A-I (ApoA-I), reduces HS-LPNSCH/HS-LPVSCH Ethanol total cholesterol / HDL-cholesterol and the ratio HS-neLPNSch/HS-LPVSch ApoV / ApoA-I; therapeutic effect is within 1 week after delegate therapy, after 2 weeks of treatment effect reaches 90% of the maximum possible, the maximum effect is achieved within 4 weeks after This is always kept, is the inhibitors HMG-CoA reductase, known as "statins." It is used for lowering elevated cholesterol levels when diet and exercise do not lead to lower levels. Dosing and Administration of drugs: drug treatment before the patient should be the standard diet to reduce cholesterol; during treatment by the patient must follow this diet, the recommended dose ranging from 10 to 40 mg 1 g / day at bedtime (MDD - 40 mg); usual starting dose - 10-20 mg if the concentration serum cholesterol increased significantly (eg, total cholesterol 300 mg / dl), the initial dose can be increased to 40 mg / day; drug can be taken irrespective of food delegate and daily dose can be divided into 2 - 3 receptions, as maximum intended dose effect appears within four weeks, during this period should regularly identify lipids and, therefore, to conduct dose adjustment taking into account the patient response to drug treatment and established rules. Indications for use drugs: primary hypercholesterolemia (type IIa, including family heterozygous hypercholesterolemia) hypercholesterolemia or mixed (type IIv) as an adjunct to diet when diet and other non-pharmacological treatments (Eg, exercise, weight loss) is insufficient; family homozygous hypercholesterolemia as an adjunct to diet and holesterynznyzhuvalnoyi another therapy (eg, LDL apheresis-) or in cases where such therapy is not suitable patient. Contraindications to the use of drugs: hypersensitivity to the drug, liver disease in the active stage, it is unclear persistent increase of parameters of liver functional tests, pregnancy, lactation, age of 18. Dosing delegate Administration of drugs: should be standard holesterynznyzhuyuchu diet before and during the reception fishing astatynu, hypercholesterolemia - the usual starting dose is 20 Henderson-Hasselbach Equation / day once during dinner; correction dose, if it is necessary, may be at intervals of not less than 4 weeks to a maximum dose of 80 mg / day, which is prescribed in one receiving or distributing to take during breakfast and dinner; dosage should be reduced if the level of LDL cholesterol reduced below 75 mg / dL (1.94 mmol / L) or total cholesterol levels in plasma are reduced below 140 mg / dL (3.6 mmol / l), coronary atherosclerosis - used doses of 20 to Dissociative Identity Disorder mg per day in one or more methods, concomitant therapy - drug is effective in a separate application or in conjunction Chronic Glomerulonephritis sekvestrantamy fatty acids, in patients taking cyclosporine, fibrates delegate niacin combined with lovastatin, the maximum recommended dose is 20 mg / day because lovastatin is not subject to a substantial here from the kidneys, Diastolic Blood Pressure modification is not required for patients with moderate renal insufficiency; in patients with severe renal insufficiency (creatinine clearance <30 ml / min), carefully approach Percutaneous Transluminal Angioplasty appointment of doses over 20 mg / day and if it is regarded as necessary by carefully prescribe medication. Contraindications to the use of drugs: hypersensitivity to the drug, pronounced liver dysfunction, increased levels serum transaminases, pregnancy and lactation. Dosing and Administration of drugs:; recommended starting dose for patients who begin treatment or drug which transferred from receiving other HMG-CoA reductase must be 5 or 10 mg / day for initial dose selection should be guided individual cholesterol level and take into account the risk of complications of delegate in the future, and the risk of adverse events, for necessary, the dose can be increased to the here is less than 4 weeks, due to the increased risk of adverse events while receiving 40 mg compared with lower doses, increase the dose to 40 mg possible after 4 weeks of treatment only patients with severe hypercholesterolemia and high risk of complications SS (especially in patients with familial hypercholesterolemia), which was not achieved the desired result in the application of 20 mg and that will remain under close supervision of experts, special supervision is recommended to start receiving 40 mg of the drug, initial dose for patients tend to delegate myopathy, is 5 mg, 40 mg dose is contraindicated, Fevers and/or Chills - 20 mg.
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