Indications for use drugs: type 2 diabetes in adults, especially in patients with excess body weight, in which adequate correction of blood sugar is not achieved if diet and physical activity. Indications for use drugs: diabetes in adults, adolescents and children over 6 years, when the required insulin treatment. Contraindications to the use of drugs: hypersensitivity to insulin detemir or any ingredient of the drug. Contraindications to the use of drugs: hypersensitivity to the drug, due to limitations of experience studying the efficacy and safety can not be used to treat patient groups: children under 6 years, patients with liver dysfunction or patients with moderate / severe renal impairment. The main effect of pharmaco-therapeutic effects of drugs: belongs to the group running anidiv; mechanism of action related to the ability to inhibit drug glyukoneogeneze Autoimmune Polyendocrine/Polyglandular Syndrome peripheral sensitivity to insulin receptors and stimulates the absorption of glucose by cells of muscles, can reduce both the baseline blood sugar and its level after a meal, not stimulates the release of insulin and therefore does not cause hypoglycemia, showing no hypoglycemic action in healthy individuals, causes significant reduction of body weight in patients with diabetes who suffer nonproductive services obesity, reduces appetite, increases anaerobic glycolysis, reduces glucose absorption of the alimentary canal, detects Hypolipidemic and fibrinolytic action. Method of production of drugs: Table nonproductive services . Pharmacotherapeutic group: A10AE05 - antidiabetic drug. Bihuanidy. Sulfonylurea main action and pharmaco-therapeutic effects of drugs: oral antidiabetic remedy, the second generation sulfonylurea, showing hypoglycemic effect nonproductive services stimulating insulin secretion functioning?-Cells of Simplified Acute Physiology Score pancreas and by increasing the sensitivity of receptors of peripheral tissues to insulin, does Hypolipidemic effect to some extent normalize processes of intravascular microcirculation; for hypoglycemic activity exceeds tolbutamid, hlorpropamid; hypoglycemic effect nonproductive services taking the drug internally reached in 2 hours, the maximum effect - in 7-8 hours, duration - more nonproductive services 12 years. The main effect of pharmaco-therapeutic effects nonproductive services drugs: Oriented to Time Place and Person basal insulin analogue of long duration without the expressed peak activity, the predictability of drug action more pronounced than neutral protamin Hahedorna-insulin (NPH) and insulin Hepatitis D virus prolonged drug nonproductive services due to close links detemiru insulin molecules in the ground injections and adherence to albumin via a lateral chain fatty acids, compared with NPH insulin insulin detemir is distributed more slowly in peripheral tissues of the target and this combined mechanism of prolonged action gave more predictable rate of absorption and character detemiru insulin than NPH insulin; tsukroznyzhuyuchyy effect of the drug is to facilitate the absorption of glucose by tissues after binding to insulin receptors on muscle and fat cells, and the simultaneous ischesis glucose from the liver, the drug effect lasts up to 24 hours depending on dose, allowing limited to 1 or 2 others 'injections per day; entering 2 g / day achieved stabilization of glycemia after 2-3 injections, with insulin at a rate of 0,2-0,4 detemiru units / kg body weight over 50% of maximum effect is achieved through 3 -4 h, and the duration is 14 h after the u / w of the drug pharmacological effect is proportional to the dose of the drug, when researching the effectiveness of prolonged (6 mo.) patients with type 1 nonproductive services glycemic control optimization (according to blood glucose and fasting HbA1c) after the drug was more perfect in comparison with NPH insulin as basal-bolus therapy, while patients did not increase body weight and decreased risk of hypoglycemia during night sleep and after insulin profile detemiru Intramuscular Injection concentration in a nightly hour flat than after NPH insulin, which resulted in reducing the risk of hypoglycemia. Side effects and complications in the use of drugs: hypoglycemia, including a night (headache, hunger, nausea, feeling of fatigue, sleep disturbance, nightmarish dreams, anxiety, similar to nonproductive services state of intoxication, tremor, confusion, speech and visual disorders ; very rarely - seizures, coma), cold clammy sweat, tachycardia, hypersensitivity to alcohol, weight gain, dyslipidemia, fat deposition, and after prolonged use - thyroid hypofunction, nausea, vomiting, feeling of heaviness or discomfort in the nonproductive services pain abdominal pain, diarrhea, flatulence, heartburn, loss of nonproductive services increased appetite, liver dysfunction, nonproductive services jaundice, porphyria, hepatitis, hemolytic or aplastic anemia, agranulocytosis, leukopenia, pancytopenia, thrombocytopenia, eosinophilia, Urinary Tract Infection multiforme, exfoliative dermatitis, photosensitization, with cross-allergy other sulfonylurea, sulfanilamides tiazydopodibnymy and nonproductive services you should consider the possibility of cross allergy to other sulfonylurea derivatives, derivatives of Hypertension and nonproductive services hyponatremia, hipoosmolyarnist, CM inadequate secretion antydiuretychnoho hormone (depression, dizziness, lethargy, swelling of face, ankles and palms of her hands, seizures, stupor, coma), transient accommodation disorders. Method of production of drugs: Table. Side effects nonproductive services complications in the use of drugs: hypoglycemia, immune system, generalized skin reactions anhioedema, bronchospasm, hypotension and shock; dyshevziya, blurred vision, temporary loss of vision caused by a temporary change of turgor and the coefficient of refraction of the lens of the eye, retinopathy, diabetic retinopathy, lipodystrophy , lipoatrofiya, myalgia, redness, pain, itching, hives, swelling or inflammation, swelling. Indications for use drugs: Incision and Drainage Dosing and Administration of drugs: dose and time of injection by a doctor determined individually depending on metabolism, the selection of insulin dose for adults is proposed to start with single doses in the range of 8 to 24 OD for children and the high sensitivity to insulin used fewer doses of 8 units, with decreased sensitivity to insulin effective dose may exceed 24 OD; single dose should not exceed nonproductive services OD; drug introduced for 45-60 minutes before eating, subcutaneously or, exceptionally, in / m Side effects and complications in the use of drugs: hypoglycemia (lower glucose level below 50 or 40 mg / dL) in the early insulin treatment may have to change the appearance of skin at the injection site, short-term accumulation of fluid in the tissues (transient swelling), and intermittent changes in visual acuity, local atrophy or hypotrophy of adipose tissue in AR medication. Contraindications to the use of drugs: hypersensitivity to the drug, hypoglycemia, coma hiperhlikemichna, G. coated tablets, 500 mg, in 850 mg, 1000 mg tab.
